The Drainage effect of mobile O2O commerce is closely related to the platform quality. However, to date there has been no measure specifically designed to measure mobile O2O commerce platform quality (MCPQ). The purpose of this study is to develop a scale for measuring MCPQ based on the IS success model. Exploratory factor analysis (study 1) and confirmatory factor analysis (study 2) were performed on 613 samples. Results showed that the scale of MCPQ is a reliable and valid instrument, and that mobile O2O commerce platform quality is a multi-dimensional construct composed of five dimensions, i.e., interface design, operational efficiency, content quality, demand responsiveness, and privacy protection.