Along with “the Belt and Road Initiative”, China’s cross-border e-commerce has been developed rapidly, which will certainly bring new challenges for talents cultivation in the Higher Education. The paper analyzes the new requirements for business talents under cross-border e-commerce. And then a cultivation system was proposed by examining the five major programs in our university. The cultivation objectives, the curriculum and the practical module are elaborated. Finally, some suggestions on the implementation of this cultivation system are put forward.