As the core area of the entire Belt and Road, Central Asian countries’ prosperity has a direct bearing on the smooth implementation of the China’s Belt and Road Initiative (BRI). The trade and economic relations between China and Central Asia are developing entirely within the worldwide economic globalization trends. In this research, we analysis the several problems that exist in the development of cross-border e-commerce between China and the Central Asian five countries at the first. And then we put forward four countermeasures for the Chinese government and enterprises investing abroad to promote the cross-border e-commerce transactions between China and the countries along the Belt and Road.