In the dynamic realm of Information Systems (IS), understanding the intricate interplay between technology, society, and theory is crucial for researchers navigating the complexities of this field. Recognizing the multidimensional nature of IS research, we propose the "Three-Pillar Model," integrating Information Technology (IT) artifact, socio-technical perspective, and theory. This model offers a comprehensive lens for literature reviews, gap identification, and knowledge advancement in IS. While these three aspects of IS research have been separately emphasized before, we integrate them into a framework to establish a baseline for assessing current literature and planning future directions in different IS research streams. The Three-Pillar Model in IS is essential, providing a balanced approach addressing instrumental outcomes and humanistic concerns. It avoids technological determinism by recognizing technology-society interplay, enhancing our ability to tackle contemporary IS challenges. The first pillar of our model, the IT artifact, represents the tangible forms of technology within IS. These artifacts not only influence individual behaviors but also shape organizational dynamics and societal structures. By considering the implications of IT artifacts, researchers can explore their dynamic properties and evaluate their transformative potential on various levels (Orlikowski & Iacono, 2001). Understanding these implications is crucial for addressing associated issues and fostering a deeper comprehension of the role of technology in contemporary society. Moving beyond the artifact itself, the socio-technical perspective constitutes the second pillar of our model. This perspective emphasizes the connection of technology and social dynamics within organizational and societal contexts. By adopting a socio-technical lens, researchers can examine the complex interactions between people and technology, thus gaining insights into the transformative power of technology on social structures and economic settings, promoting inclusive and human-centered IS research (Sarker et al., 2019). The third pillar of our model, theory, serves as the foundation upon which IS research is built. Theoretical frameworks enable researchers to conceptualize, explain, and predict phenomena within the IS domain, thereby advancing knowledge and guiding research endeavors (Gregor, 2006). Integrating established and new theories catalyzes innovation, addressing contemporary IS challenges. By integrating IT artifact, socio-technical perspective, and theory, the Three-Pillar Model offers a cohesive IS research approach. It fosters a holistic understanding of complex phenomena, identifies future exploration areas, and drives innovation. This approach addresses evolving IS challenges, contributing to knowledge advancement and practical solutions.