Although technology-mediated interruption has received substantial research attention over the past several years, most of the existing research investigates the effects of interruptions only from the perspective of the interrupted person. In this paper, we aim to answer the recent calls for research from the interrupters’ perspective and develop a research model based upon Conservation of Resources (COR) theory and Action Regulation Theory (ART) to explore the effects of supervisors’ technology-mediated interruption behavior. In this model, we propose that supervisors’ technology-mediated interruption behavior leads to information overload and sense of control, which impact work/non-work exhaustion and work/non-work performance, and eventually affect the supervisors’ perception of work-life balance. We also propose that personal characteristics including supervisors’ sense of power and computer experience will moderate the relationships between supervisors’ technology-mediated interruption behavior and information overload/sense of control. We plan to test the proposed research model using experience sampling methodology (ESM).