What are the technologies that will transform business and drive the research agenda for the IS field in the years to come? Which innovations, platforms, and paradigms will become dominant, and which others will ultimately pass into obscurity? In this panel discussion, we will seek answers to these questions from those with a unique and unmatched perspective. The leaders who have witnessed the birth and development of the IS field during the past 40- 50 years will draw on their experiences and their deep knowledge of the field to identify the characteristics of technologies that have changed business in the past. They will also explain how and why today’s innovations will change both research and practice going forward. Their insights have the potential to identify topics for researchers to examine now and in the years to come.