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The challenge of globalization the ability to respond quickly according to changes in market demands and competitions, is the driving force for organizations to optimize their business strategies and operations regularly. Customer preferences and needs change constantly, resulting in pressingly intense competitions. Time sensitive real-time transaction is becoming the common denominator for successful businesses. Information also needs to be available to anyone from anywhere at anytime. As the global economy shifts toward the mobile economy, enterprises need to be progressively more flexible and globalize. Mobile businesses open up new opportunities for innovative enterprises and give them new means of communications with customers and employees. In a changing business landscape, mobile business addresses new customer channels and integration challenges. This paper provides a broad discussion on the changing landscape of business: from e-business to m-business. Several issues will be addressed, such as value chain, the data access of mobile computing, m-business application framework, and the future development of mobile computing (e.g. 4G wireless). All of these efforts attempt to provide an overview and schematics for the integration of modern ebusiness application strategies into future m-business practices. This paper will show that any innovated business strategy should be built upon target stakeholders. With mobile technologies, enterprise applications will go beyond the four walls of organizations to a workforce on the move.