This study uses a novel approach to address the wicked problem of the need for a standardized approach to evaluating performance in e-learning contexts in medical education. Leveraging the design science research methodology, the study develops a weighted performance scoring model using multiple methods, including bibliometric analysis, systematic literature review, principal component analysis, statistical modeling, and expert judgment technique. This model is designed as the critical success factors to guide the design of e-learning systems and key performance metrics to provide a standardized performance evaluation approach, building resilience and adaptability in the ever-evolving healthcare landscape. The model was implemented at the Nelson Mandela School of Medicine, University of KwaZulu-Natal, South Africa, and demonstrates robustness in both design and evaluation dimensions through expert evaluation. The study contributes to the domain by providing a structured approach for designing and evaluating e-learning courses, aiming to enhance the quality of e-learning in medical education globally.