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Clinical decision support systems (CDSS) can prevent situations in which doctors prescribe a drug to a patient that causes a harmful reaction with another drug that a patient already takes (adverse drug events (ADE)). This can be achieved through generating medication alerts in the moment that a drug is prescribed. Researchers have paid considerable attention to how to design these alerts in the best possible ways, however, largely with inconclusive results. We tackle this body of literature using a ‘problematizing’ approach that enables to understand why research results are inconclusive by disclosing underlying assumptions in a body of literature that have over time shaped a scholarly debate into a particular direction. We uncover four problematic assumptions, offer alternatives to these assumptions and outline potentials to implement our ideas in future research projects.



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