Assessing effective use of health Management information systems (HMIS) in low-resource settings is critical to improving public health. However, mainstreaming information systems into daily practice can be challenging in dynamic, isolated settings where technology adoption is often not a priority. It is essential to design tools that address user needs and are deemed useful. In this paper, we propose a generic framework that applies effective use theory and affordance actualization theory to assess how HMIS are used efficiently in organizations and identify areas operational vulnerabilities. The proposed study uses a mixed-methods approach to data collection and analysis. This framework contributes to the information systems utilization literature by providing a method for contextualizing the assessment of effective utilization by giving relevance to specific information management tasks. From a practical perspective, it aims to guide information systems practitioners in low-resource environments in strengthening their digital organizational information systems.