Contemporary healthcare information systems (HIS) rely heavily on IT/IS infrastructures to manage primary and essential services. Given that hospitals and HIS have been facing various disruptions from disasters, it is essential to take an integrative approach to help prepare effective coping strategies in disaster situations. To date, little is known about how HIS resilience is achieved. While Information Systems Assurance, IT Capability and Effective HIS use are important, the high degrees of HIS complexity and Interdependence of health information systems also have an impact on resilience. This study integrates a socio-technical perspective and theorizes the effect of disaster experience and influential factors for HIS resilience. HIS resilience will enable healthcare organizations to sustain the continuity of effective performance in terms of critical medical services in a disaster situation.