New ways of combining digital and physical innovations, as well as intensified inter-organizational collaborations, create new challenges to the protection of organizational knowledge. Existing research on knowledge protection is at an early stage and scattered among various research domains. This research-in-progress paper presents a plan for a structured literature review on knowledge protection, integrating the perspectives of the six base domains of knowledge, strategic, risk, intellectual property rights, innovation, and information technology security management. We define knowledge protection as a set of capabilities comprising and enforcing technical, organizational, and legal mechanisms to protect tacit and explicit knowledge necessary to generate or adopt innovations.