Failed software projects are often the result of an unsystematic transfer of business requirements to the implementation. This deficit led to the specification of the Model Driven Architecture (MDA). It claims a consistent use of conceptual models for the software development process from requirement analysis to technical specification of software. The MDA reduces the gap between the business level and the information technology (IT) level by defining a methodological framework to link these levels (Business-IT alignment). We will present the use of an MDA in health care domain. For this purpose, we show how the paradigm of MDA can be configured to implement medical application software based on a telemedical IT platform (telehealth platform). Additionally to the conceptual structure of the developed approach and the domain-specific alignment, lessons learned from the experiences gathered during design process will be formulated as assistance for similar projects and substantiated with an exemplary application.