This paper puts forward the background of the topic, expounds the research status of waste transfer center location at home and abroad, and summarizes and establishes a nonlinear mixed 0-1 planning type of multi transfer center location model in the relevant theory. The model gives the location constraints when the alternative point of the transfer center has been determined. Under the constraints, it mainly considers the total transportation cost of the waste passing through the transfer center, the treatment cost due to the classification, compression and packaging of waste, and the fixed investment cost of the construction of the waste transfer center, so as to minimize the total cost of these four parts. Based on Gaode map, on the basis of establishing the model, the investigation, statistics and analysis data are substituted to solve the optimal location result.