In order to explore the relationship between regional e-commerce and other regional industries, this paper uses the input-output table of Hubei Province in 2012. By using the input-output analysis method, the consumption coefficient, distribution coefficient, influence coefficient and sensitivity coefficient of Hubei Province are obtained, and the relationship between regional industries and regional e-commerce development is discussed. It is considered that the level of regional e-commerce in Hubei Province is not high, but it has great development potential.