Several studies have highlighted the adverse consequences of information system (IS) overuse. To expand the knowledge on this heated topic, this paper aims among the first to explore the association between nomophobia, a manifestation of smartphone excessive use, and life satisfaction mediated by psychological wellbeing, as well as academic performance. On the other hand, this paper also targets the reverse procedure, namely if life satisfaction mediated by both psychological wellbeing and academic performance prompts nomophobia. To empirically test the established model, a big-scale systematic random sampling over 10 thousand responses is plan to implement. The survey questionnaire collected demographic information and actual grade-point average (GPAs), as well as responses to scales including the nomophobia, psychological wellbeing (consisted of perceived stress, depression, and loneliness), and life satisfaction.