Based on the case studies of e-commerce activities in six counties of China’s eastern, middle and western regions respectively, this paper has probed into the characteristics of e-commerce development of each county, which are then classified into four development models of county-level e-commerce in China, featuring the integration and aggregation of resources endowment and production factors. The paper further analyzes the key factors contributing to the success of county-level e-commerce development, in a bid to provide reference and guidance for other counties in their e-commerce activities.