This paper defines the concept of regional e-commerce by analyzing the literature. According to the definition, this paper extracted the core indicators of regional e-commerce development, and used the principal component analysis to evaluate the development level of regional e-commerce. Finally, this paper analyzes the impact factors of regional e-commerce development from qualitative and quantitative perspective and puts forward relevant hypotheses. Regression analysis is used in this paper to validate the hypothesis in the analysis of the influencing factors of regional E-commerce. The empirical results has showed that the industrial structure, network coverage, logistics infrastructure are key factors of regional e-commerce development.