The practical teaching is the key link of training the students’ practical and creative ability in major of information management and information system. On the basis of analyzing the training goal and social demand of the major, an innovative practice system based on actual projects is constructed to solve the main problems exist in the practical teaching, by combining with the successful experience of the practical teaching innovation in Wuhan University of Science and Technology. The system provides a good practical teaching environment and an innovation practical platform for the cultivation of high quality innovation talents. To study in actual projects will accumulate the students’ project experience, cultivate their innovation consciousness and promote their competition ability.