Digital business ecosystems (DBE) conception started gaining popularity from 2002 and currently is widely deployed by various EU regions aiming to facilitate regional economic growth. DBE brings many benefits for SMEs enhancing competitiveness and position in the market. DBE solution vary so regions a facing problem how to selected appropriate solution and what are the key success factors for such solution implementation. This paper discuss experience from 6 DBE good practices pilot implementation identifying key success factors and providing recommendation for future DBE transfer.