The patient is the lifeblood of the hospital and only win customers can win the future. When choosing a hospital, in addition to the strength of the medical treatment of the hospital itself, patients considering most are the services of the hospital which is the very factor that can influence customer making decision. Clearly, the needs of patients can’t be achieved in overcrowded public hospitals. This paper starts from the content of E-Business, analyzes the current situation and problems of private hospital development, points out that development of E-Business to enhance customer relationship management is the only way to solve the practical problems of private hospitals, gives personal attention of private hospitals overall E-Business solutions and development strategies.