The introduction of Enterprise Social Media (ESM) has been driven by many factors that can be grouped into organizational activities namely, communication, cooperation, collaboration, and connections in real-time and asynchronous times. However, research shows that organizations struggle with enterprise-wide adoption. Research also indicates that one of the factors impeding adoption is organizational culture. It is essential to further understand the cultural dimensions that contribute to readiness for ESM because such understanding could help organizations better prepare for ESM adoption. This paper, therefore, compares two of the most prominent cultural studies, Hofstede’s and Schwartz’s cultural frameworks, within the context of ESM.