The knowledge management literature has recognized the importance of knowledge transfer and acquisition on organizational success and viability. However, there is a dearth of research that has explicitly focused on knowledge transfer and acquisition in the information systems (IS) outsourcing context, and in particular, the factors that facilitate or impede such transfer. This paper attempts to fill this gap by examining the factors that have been cited as significant influences on the ability to transfer knowledge from the vendor to the client organizations in the context of IS outsourcing. In this study, the factors are categorized into four groups and these groups are integrated into a conceptual framework. Conclusions are drawn about how effective knowledge transfer and acquisition can be managed in the context of IS outsourcing.