From the face saving perspective, this paper attempts to investigate the factors influencing physicians’ resistance of clinical decision support systems (CDSS) in outpatient settings. We develop a research model which posits that physician resistance of CDSS is determined not only by their rational perceptions of CDSS’ usefulness, but also by their sociocultural perceptions of face loss. To contextualize theory development, we include a moderator – time pressure, which is unique for physicians’ decision context. By proposing that time pressure can strengthen both the negative impact of perceived usefulness and the positive impact of face loss on CDSS resistance, we attempt to demonstrate that time pressure’s effects are paradoxical: it plays dual roles in both facilitating and reducing resistance. This paper takes a unique perspective to understand physician resistance behavior, and we expect it to make an important contribution to HCI research and practice.