This study examined the antecedents and outcomes of interaction in asynchronous online learning courses. The research model was tested by using a Partial Least Squares analysis on the survey data. A total of 397 valid unduplicated responses from students who have completed at least one online course at a university in the Midwest were used to examine the structural model. All hypotheses except one in this study were supported. We found that all three factors - course structure, self-motivation, and learning styles - influenced students’ interaction with the instructor and classmates. Further, there is a positive relationship between interaction and students’ satisfaction. This is in accordance with the findings of the extant literature on student satisfaction we have discussed. The structural model results also reveal that user satisfaction is a significant predictor of learning outcomes, but the model failed to support the relationship between interaction and the learning outcomes of e-learning classes in relation to face-to-face classes.