Recent supply chain disruptions following Covid-19 and international crises have led to changing paradigms in supply chain design. Likewise, data-driven technologies housed under the term Industry 4.0 have an increasing impact on how supply chains are orchestrated and shaped. This paper gives an overview to several examples of recent and expectable trends in supply chain design. Advanced manufacturing technologies, data-driven technologies in logistics and supply chain management, electrification of vehicles, as well as microchips and semiconductor manufacturing are described as representative drivers of new forms of supply chain design. In this context, a special emphasis is devoted to European initiatives such as the European Chips Act or the European Battery Alliance. Examples such as manufacturing ecosystems or platform based manufacturing are given as well as locally independent supply chains that provide potentials for supply resilience and sustainability. The paper concludes with a research agenda that includes seven areas for future research, including changes in supply chain structure, changes in inter-firm interaction, integration of small and medium-sized enterprises, changing roles of humans and new forms of business models and collaboration. In this context, the interrelations between technologies (product and production level) as well as the research avenues must be emphasized.