Since technostress has been linked to tremendous productivity losses for U.S. organizations, this research-in-progress examines whether computer self-efficacy (CSE) can help individuals cope (i.e., deal) with such technological stressors as technology-mediated (T-M) interruptions (e.g., instant messages). Investigating the role of CSE in this context sheds light on the ways in which employees can maintain a positive well-being despite the presence of technological stressors. More specifically, we tried to understand the complex relationships between technology, stress, and information systems-related individual differences to provide businesses with an understanding of the conditions under which employees can work effectively. Drawing from the cognitive psychology and the technostress bodies of literature, we hypothesize that CSE moderates the link between the frequency with which such T-M interruptions as instant messages appear and stress. This paper proposes a laboratory experiment to test our model and concludes with an overview of its expected contributions.