This research-in-progress presents a difficult healthcare problem, namely how to reduce the costs associated with chronic diseases. A comprehensive Web-based disease management system is proposed as a potential solution to help patients with chronic disease more effectively self-manage their disorders. A proposed research agenda is presented using a design science research approach. Theories capable of informing the design of the proposed solution are discussed including social learning theory and the theory of planned behavior. Design parameters are described and potential design ideas are presented.