This article discusses a home telehealth project that employs innovative informatics and telemedicine technologies to meet the needs of a Veterans Affairs Medical Center (VAMC). We provide background information concerning the project and program management issues inclusive of the methods for patient selection process, the decision support system used in this process, and descriptions of the home telehealth technologies. Our goal is to articulate program management insights incurred in the implementation of the project to provide useful information to other healthcare systems considering home telehealth as a contemporary option for care delivery.