The transformation of the world into a highly technological place has led to the evolution of learning from traditional classroom to e-learning, using course management systems (CMS). E-Learning offers a range of advantages over traditional pedagogical methods, providing a bridge for students with sensory limitations, who otherwise, find themselves at a disadvantage. This study evaluates the accessibility, usability, interactivity, and responsiveness of popular CMS, and examines if an accessible and usable CMS impacts the performance of physically challenged students. For this purpose, university students having sensory limitations were surveyed. The results revealed some interesting facts about online education, besides identifying an area of improvement.