A review of IT trade publications and MIS research literature on IT-business alignment confirms the fact that, as a top concern for CEO’s and CIO’s, problems associated with a lack of an optimal level of alignment between business and IT functions within organizations remain as a continuing challenge for IT and organizational management. In attempts to explicate the IT-business alignment construct, researchers have formulated definitions of the construct, and they have proposed frameworks and models. Research studies on alignment have identified potential organizational impacts of alignment and have proposed prescriptive measures for achieving a higher degree of IT-business alignment in organizations. Given this body of research, an identification of key issues yet to be fully addressed by the existing research would guide additional research on IT-business alignment. Based on the results of a literature review, this paper provides a characterization of the research findings to date and proposes topics for additional research intended to extend the knowledge on IT-business alignment.