The paper discusses, based on a systematic literature review, the following question: “How suitable is Design Science Research (DSR) as a methodology for information systems' studies?” From a rough initial screening of 1605 scientific papers, using several filtering criteria, 83 papers were finally selected and analyzed. It was possible to identify three types of studies among them. Some studies involved the use of DSR without the support of any other external methods. Some presented studies using DSR in addition to other research methods. And, finally, some papers were concerned with the contextualization and discussion of DSR, as the object of the study itself. The paper aimed to discuss the relevance of DSR based on the remarks of those who used it in the studies that were analyzed for this project.