The nexus between Business and IT research is complex. Due to extended research over time, the context of business-IT alignment has resulted in many different conceptualisations that can be applied to ongoing research. It is challenging to select and adopt a suitable approach to study business-IT alignment across any given field due to the variability of the existing conceptualisations. This study reviews the existing literature to identify alignment conceptualisations and contributes to both theory and practice. Theoretically, through the uncovering of gaps in the literature a taxonomy has been developed which can be used as a guide to select an appropriate alignment lens for business-IT alignment studies. In practice, it is expected that this taxonomy will be beneficial for conceptualising the structure and philosophies underpinning future alignment studies. To validate the taxonomy, the paper presents a case study in healthcare applying the developed taxonomy to investigate alignment of big data in health.