The rapid development of digital healthcare brings many benefits to the healthcare industry and bio-science. Precision healthcare is considered one of the most promising directions for healthcare development. The practice of precision healthcare is based on genetic sequencing and then prescriptive and predictive analytics based on big data. However, it creates a serious issue of how to encourage the opting-in of patients so that more robust and reliable models may be built. Blockchain, as a promising, secure, transparent and “trustless” technology, may be the solution to address the concern of patients. However, to date, blockchain has not been developed for precision healthcare systems. To address this research gap, this paper proposes a blockchain-based, smart informed consent architecture using design science. The solution seeks to determine whether blockchain may be applied to precision healthcare to improve service outcomes by increasing the opting in of patients.