This paper reports the follow-up research of “Challenges and Possibilities for the Household Medicine Lease (HML) System Viewed in light of CRM,” presented in Conf-IRM 2009. With the ongoing insufficiency of medical services, the traditional Japanese business model of household medicine lease (HML) system has now been successfully implemented in the Association of Southeast Asian Nations. However, because of the rapidly aging population, Japan has currently been suffering from difficulties in coping with the rapidly increasing demand for medical services. Our study aims to design a system of everyday healthcare in combination with the HML system and medical monitoring system based on international standard and provides an interoperable platform that meets various conformity requirements. This study presents features of the self-medication system based on data from monitoring devices certified by Continua Health Alliance, and then presents the concept and challenges of community-based self-medication designed to suppress increase in nationwide healthcare costs.