With the widespread use of information and communication technologies (ICTs) in organizations, ICTs have become a crucial part of daily work. However, although the implementation of ICTs in organizations has greatly improved the production efficiency and quality, negative outcomes, such as stress, have arisen as well. Stress induced by ICTs in work-specific contexts is termed technostress. This paper theorizes the mediating effects of affective attitudes toward the use of ICTs on the relationship between technostress creators (the independent variable) and end-user performance (the dependent variable). The possible contributions of this paper include: 1) theoretically, the mediating effect of affective attitudes between technostress creators and end-user performance are examined to complement the technostress research model; 2) practically, those interventions found to influence the mediating variables may be used to promote the end-user performance if the mediating effect is significant. The findings of our study may open new door to more cost-effective and powerful solutions for improving the ICTs use effectiveness.