An ontology is an explicit specification of a conceptualization. It is a special kind of conceptual model that is an ultimate deliverable of ontology engineering. The ontologies themselves are design artifacts. In information systems research, the ontology is increasingly widely accepted and used for solving various information system problems. However, it is not clear how research into ontology-based applications can be understood from the viewpoint of design science research in information systems. Therefore, this paper is a first attempt to illustrate ontology-based applications through the lens of design science. Our method is based on a review of the literature and retroactive analysis of two exemplar articles from two top-tier information systems journals. As a result, we find that ontology-based applications fit very well into the overall framework of design science research in information systems.