This study evaluates the effects of KM infrastructure and KM processes on the organization’s KM effectiveness. The moderating effect of interpersonal trust on the relationship between KM processes and KM effectiveness is also explored. KM infrastructure has three sub-constructs: KM technology, KM structure, and KM culture; whereas the four sub-constructs forming KM processes are: knowledge acquisition, knowledge conversion, knowledge application, and knowledge protection. Survey data were collected from teaching staff of post-secondary institutions in Hong Kong. PLS were used for testing the measurement and structural models. The results support the hypotheses and are consistent with the literature. This research contributes to the literature by empirically validating the proposed research model in educational setting.