Agriculture has evolved dramatically over the past few decades, principally due to advances in machinery. Another evolution is at hand due to technological advances such as artificial intelligence, sensors, etc. These emerging technologies are anticipated to enhance not only the productivity of agri-culture but also its sustainability. The past century has seen an increasing focus on sustainability, also called sustainable development. Research indicates that agricultural systems and human development are irrevocably connected since agricultural systems are the principal channel to produce food for society. Almost all recent definitions of sustainability place emphasis on an ecological perspective. That is, the idea that there is an intimate relationship between human society, the economy, and the natural environment. In other words, humans must coexist amicably with the natural universe if there is a desire to “persist, adapt, and thrive” forever on Earth. Therefore, a common model of sustainability illustrates the interrelationship between three Es, namely, the environment, economy, and social equality (or equity). This paper aims to understand better the role of innovation, how natural and technological approaches contribute to economic and sustainability objectives in agriculture and pathways for future IS research in the agriculture domain.