A number of researchers on Science and Technology Studies (STS) have criticized the western view treating knowledge as objective and universal, with the argument that all knowledges are locally situated. In this article we draw on this view of decentring of scientific knowledge and on the concept of boundary objects to discuss an empirical case of a ‘global’ collaborative network called Health Information System Programme (HISP) involving a number of countries in a process of knowledge creation and sharing. The network consists of knowledge objects with seemingly universal characteristics shareable across sites. The paper discuss the ‘localness’ of the knowledge produced by looking at its originality and how it is made mobile, thereby giving it the seemingly universal characteristics. The article further, discuss how the involved multiple social worlds characterized by different knowledge practices, cultures and visions, participate through boundary objects shareable across the network and thereby contribute new knowledge in the network. The collective boundary objects created and shared within the network play a significant role in creating synergies which in turn sustains the involved countries’ local initiatives.