The research that is described in this paper focuses on incorporating theories of individual differences in information processing within the context of mobile hypertext and hypermedia interactive environments. Based on previous findings of the authors in the field of adaptive eLearning, the main purpose was to enhance the quality of information presentation and users’ interactions in the Web by matching their specific needs and preferences. Our more recent experiments, explore how to improve learning process by adapting course content presentation to student cognitive styles and capabilities in mobile environments such as PDA phones. A framework has been developed to comprehensively model student’s cognitive styles and visual working memory span and present the appropriate subject matter, including the content, format, guidance, etc. to suit an individual student by increasing efficiency during interaction. Main aim is to overcome constraints like small screen size and processing/memory capabilities for navigation enhancements that limit the presentation and guidance of the material. An increase on users’ satisfaction as well as more efficient information processing (both in terms of accuracy and task completion time), has been observed in the personalized condition than the original one. Consequently, it is supported that human factors may be used in order to enhance the design of mobile hypertext (or hypermedia) environments in a measurable and meaningful way.