The aim of this review is to contribute to the understanding of the challenges faced by companies in achieving alignment between governance structure and innovation strategy. Corporate governance is essential to ensure that companies are managed responsibly and efficiently, which can be a challenge when it comes to integrating innovation into their business strategy. The PRISMA protocol was used to systematize the results of the literature review. Based on the literature review, we can conclude that the main challenges faced by companies when trying to align their governance and innovation strategies stem from endogenous factors. It is also worth noting that the presence of top management as well as stakeholders directly involved in the process will lead to an increase in innovation. This study aims to pave the way for future research where it is possible to identify and assess innovation opportunities in a constantly changing environment.