Several studies have highlighted the adverse consequences of information system (IS) excessive use. To expand the knowledge on this heated topic, this paper aims among the first to explore the association between nomophobia and life satisfaction mediated by psychological disorders. A big-scale systematic random sampling of over 10 thousand responses is implemented to test the established model empirically. The survey questionnaire collected demographic information, as well as responses to scales, including the nomophobia, psychological disorders (consisted of perceived stress, depression, and loneliness), and life satisfaction. Our results revealed that smartphone usage positively contributes to the development of nomophobia among college students. Noticeably, the relationship between nomophobia and life satisfaction is mediated by psychological disorders. This study offers a flexible reference to understand the occurrence of smartphone usage-related adverse effects through internalization, therefore facilitating future studies designed to discover more comprehensive effecting mechanisms of IS use.