Designing for usability and locally relevant features for end-users in generic ‘product’ or ‘packaged’ enterprise software projects is challenging. On the generic level, designers must aim at supporting variety, which is contradictory to the specificity needed to make user interfaces usable, and functionality relevant to end-users within specific organizational contexts. Also, addressing these concerns during the implementation of generic software is difficult due to limitations in the design flexibility of the software, time and resource constraints, possible maintenance issues following customization, and a lack of design methods appropriate for the context of software implementation. Reporting from an ongoing Action Design Research project following a global generic health software, this paper conceptualizes a Generic Software Design Lab that aims to equip design on the level of software implementation with flexibility, tools, and methods to efficiently localize generic software. By conceptualizing the approach and discussing how it works to strengthen implementation-level designers’ ability to address usability and local relevance, the paper contributes with learnings to research and practice related to design, development, and implementation of generic software.