As businesses reconfigure their value chains and scale up their global expansions, they have to cope with a myriad of complex IT management challenges. This research examines how enterprises realign their global IT strategies for scale, speed, and innovation. Anchored in the IT governance literature, we seek to unravel the required governance structures and processes in balancing the inherent global-local tensions. Through field interviews with CIOs of global enterprises with established Asian presence, we derived a research framework for global IT management. Our findings suggest evolving global-regional-local structural elements in global IT organization supplemented by the institution of horizontal/linking mechanisms. Specifically, the key tension points appear to be in the flexible design of IT service delivery, the facilitation of IT innovation flow, and the nurturing of a global IT management mindset.