This paper describes a new framework for technology acceptance research. Next to an information-system specific belief context, an individual’s personality context and an overall technology-related context are introduced. It is primarily introduced to explore antecedents of technology acceptance’s independent constructs. The framework is proposed so that each of its tiers can host a model best describing the population under examination. The three tiered framework is then operationalized whereby personality is measured through the Five Factor Model, overall technology beliefs are reflected by the Technology Readiness Index and information system –specific beliefs are covered by the Unified Theory of Acceptance and Use of Technology. This research model is tested in a large university hospital setting, where the technology under scrutiny is an Electronic Patient Record.