Firms have invested over $15 billion in the past three years on new information technology and software in their manufacturing plants. In this study, we document how the implementation of new types of manufacturing practices has impacted the types of information technology investments in manufacturing plants. We present a conceptual model to develop hypotheses about relationships between manufacturing practices and the choice of information systems at the plant level. Analysis of cross-sectional survey data from 932 manufacturing plants provides strong empirical support for our hypotheses about how manufacturing practices influence decisions regarding adoption of plant-level IT applications.