Precision Healthcare (PHC) is a disruptive innovation in digital health that can support mass customisation. However, despite the potential, recent studies show that PHC is ineffectual due to the lower patient adoption into the system. This paper presents a Blockchain-enabled PHC ecosystem that addresses ongoing issues and challenges regarding low opt-in rates. Soft Systems Methodology was adopted to create and validate UML design artefacts. Research findings report that there is a need for data-driven, secure, transparent, scalable, individualised and precise medicine for the sustainability of healthcare and suggests further research and industry application of explainable AI, data standards for biosensor devices, affordable Blockchain solutions for storage, privacy and security policy, interoperability, and user-centricity.