Disaster relief operations rely on reliable real-time information sharing during disasters to coordinate scarce resources and save lives. The Internet of Things (IoT) has recently been regarded as an important technology for enhancing information sharing in disaster response operations to achieve effective coordination, accurate situational awareness, and comprehensive visibility of operational resources. Despite its relevance, its adaptation and implementation have been fraught with complexity. This research aims to understand the IoT enablers of humanitarian supply chain coordination. Seven dimensional enablers have been formulated by reviewing the literature and validating with practitioners’ opinions. A structural model is then developed using the Decision-Making Trial and Evaluation Laboratory (DEMATEL) technique that addresses the interdependencies of IoT enablers in humanitarian supply chain coordination. Finding provides insights into the interplay between management support, IT infrastructures, and third-party logistics service providers as key enablers towards adaptation and implementation of IoT in humanitarian supply chains. Results provide important implications and insight to decision-makers in international humanitarian organizations toward adaptation and implementation of IoT systems in humanitarian supply chains.