Regional collaborative innovation is an important issue in the development of Guangdong-Hong Kong-Macao Greater Bay Area. It promotes the exchange of science and technology resources among cities and regions, and realizes the coordinated development of science and technology in the Great Bay Area. This study examines the collaborative development in the Great Bay Area from the perspective of regional collaborative innovation. The development of regional collaborative innovation is mainly composed of four elements: finance, science and technology, transportation and education. In the case of ShenzhenHong Kong Youth DreamWorks in the Qianhai Shenzhen-Hong Kong Cooperation Zone, this study obtains the residents' views on the collaborative development of science and technology innovation, as well as the evaluation of the performance of the four major elements by questionnaire survey. This study will provide suggestions for the Greater Bay Area to further strengthen collaborative innovation and deepen mutual cooperation in the future development